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Observe Closely (3)pentobarbital will reduce the level or result of diazepam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Strong or moderate CYP3A4 inducers could enhance fee of diazepam elimination; hence, efficacy of diazepam might be reduced.pentobarbital will decrease the level or outcome of levaml